The Nitrate-Nitrite-Nitric Oxide Pathway: Potential Role in Mitigating Oxidative Stress in Hypertensive Disorders of Pregnancy

PO Barbosa, JE Tanus-Santos, RC Cavalli… - Nutrients, 2024 - mdpi.com
Hypertensive diseases of pregnancy (HDPs) represent a global clinical challenge, affecting
5–10% of women and leading to complications for both maternal well-being and fetal …

Should the non‐canonical pathway of nitric oxide generation be targeted in hypertensive pregnancies?

EC Cottrell - British Journal of Pharmacology, 2023 - Wiley Online Library
Hypertension in pregnancy is prevalent, affecting around 10% of pregnancies worldwide,
and significantly increases the risk of adverse outcomes for both mothers and their babies …

Nitrate promotes the growth and the production of short-chain fatty acids and tryptophan from commensal anaerobe Veillonella dispar in the lactate-deficient …

JH Hung, SM Zhang, SL Huang - Applied and Environmental …, 2024 - journals.asm.org
Veillonella spp. are nitrate-reducing bacteria with anaerobic respiratory activity that reduce
nitrate to nitrite. They are obligate anaerobic, Gram-negative cocci that ferment lactate as the …

Association between oral microbial nitrate metabolism and poor prognosis in acute ischemic stroke patients with a history of hypertension

Y Ren, J Liang, W Hu, J Xie, Y Zheng… - Journal of Oral …, 2024 - Taylor & Francis
Background Oral microbes mediate the production of nitric oxide (NO) through the
denitrification pathway. This study aimed to investigate the association between oral …

Investigating the association between nitrate dosing and nitrite generation by the human oral microbiota in continuous culture

T Willmott, HJ Serrage, EC Cottrell… - Applied and …, 2024 - Am Soc Microbiol
The generation of nitrite by the oral microbiota is believed to contribute to healthy
cardiovascular function, with oral nitrate reduction to nitrite associated with systemic blood …

RISING STARS: Bumps and bacteria: influence of the maternal microbiota on pregnancy outcomes

T Willmott, EC Cottrell - Journal of Endocrinology, 2024 - joe.bioscientifica.com
During pregnancy, all major physiological systems undergo remarkable changes, driven
largely by alterations in the maternal hormonal milieu. In healthy pregnancies, maternal …

Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research

TE Post, C Denney, A Cohen, J Jordan… - British Journal of …, 2024 - Wiley Online Library
Aerospace medicine required controlled terrestrial models to investigate influences of
altered atmosphere conditions, such as hypoxia, on human health and performance. These …

“Every beet you take”: lowering systolic blood pressure and improving vascular function/exercise capacity via the dietary nitrate–nitrite–NO pathway in patients with …

AJ Webb - European Respiratory Journal, 2024 - Eur Respiratory Soc
Extract 15 years ago in the European Respiratory Journal, Mannino et al.[1] presented their
report identifying an increased risk of developing hypertension in patients with COPD …

Inter-individual differences in the blood pressure lowering effects of dietary nitrate: A randomised double-blind placebo-controlled replicate crossover trial

E Hayes, S Alhulaefi, M Siervo, E Whyte, R Kimble… - medRxiv, 2024 - medrxiv.org
Purpose: Dietary nitrate supplementation increases nitric oxide (NO) bioavailability and
reduces blood pressure (BP). Inter-individual differences in these responses are suspected …