Ca2+ entry into cells of the peripheral immune system occurs through highly Ca2+-selective
channels known as CRAC (calcium release-activated calcium) channels. CRAC channels …

The nucleoprotein AHNAK is an unusual and somewhat mysterious scaffolding protein
characterised by its large size of approximately 700 kDa. Several aspects of this protein …

Ovarian cancer is the most lethal gynecological malignancy with high recurrence rates and
low survival rates, remaining a disease of high unmet need. Cancer immunotherapy, which …

Given the manifold ways that depression impairs Darwinian fitness, the persistence in the
human genome of risk alleles for the disorder remains a much debated mystery …

Allicin (diallyl thiosulfinate) is the major thiol-reactive organosulfur compound produced by
garlic plants (Allium sativum) upon tissue damage. Allicin exerts its strong antimicrobial …

Despite the high prognostic value of immune infiltrates in colorectal cancer (CRC),
metastatic disease remains resistant to immunotherapy by immune checkpoint blockade …

MicroRNAs (miRNAs) regulate specific immune mechanisms, but their genome-wide
regulation of T lymphocyte activation is largely unknown. We performed a multidimensional …

S100A10 (p11) is an emerging player in the neurobiology of depression and antidepressant
actions. p11 was initially thought to be a modulator of serotonin receptor (5-HTR) trafficking …

Genetic polymorphisms of the L-type voltage-gated calcium channel (VGCC) are associated
with psychiatric disorders including major depressive disorder. Alterations of S100A10 (p11) …

In T lymphocytes, calcium ion controls a variety of biological processes including
development, survival, proliferation, and effector functions. These distinct and specific roles …