Abstract BACKGROUND Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases
that catalyze post-translational modifications of proteins. Together, they respond to …

Sirtuins are a highly conserved family of proteins whose activity can prolong the lifespan of
model organisms such as yeast, worms and flies. Mammals contain seven sirtuins (SIRT1 …

Calorie restriction (CR) extends life span in diverse species. Mitochondria play a key role in
CR adaptation; however, the molecular details remain elusive. We developed and applied a …

Abstract Sirtuins (SIRT1–SIRT7) are unique histone deacetylases (HDACs) whose activity
depends on NAD+ levels and thus on the cellular metabolic status. SIRTs regulate energy …

SIRT3 is a member of the sirtuin family of NAD+-dependent deacetylases, which is localized
to the mitochondria and is enriched in kidney, brown adipose tissue, heart, and other …

Background Maintaining skeletal muscle mitochondrial content and function is important for
sustained health throughout the lifespan. Exercise stimulates important key stress signals …

Sirtuins are a family of NAD+-dependent protein deacetylases/deacylases that dynamically
regulate transcription, metabolism, and cellular stress response. Their general positive link …

SUMMARY The Mediterranean blue mussel, Mytilus galloprovincialis, an invasive species in
California, has displaced the more heat-sensitive native congener, Mytilus trossulus, from its …

The pyridine nucleotides, NAD+ and NADH, are coenzymes that provide oxidoreductive
power for the generation of ATP by mitochondria. In skeletal muscle, exercise perturbs the …

Ageing can occur at different rates, but what controls this variable rate is unknown. Here I
have developed a hypothesis that vitamin D may act to control the rate of ageing. The basis …