The drug discovery process is a rocky path that is full of challenges, with the result that very
few candidates progress from hit compound to a commercially available product, often due …

The aminergic family of G protein-coupled receptors (GPCRs) plays an important role in
various diseases and represents a major drug discovery target class. Structure …

Artificial intelligence is revolutionizing protein structure prediction, providing unprecedented
opportunities for drug design. To assess the potential impact on ligand discovery, we …

Rational drug design for G protein-coupled receptors (GPCRs) is limited by the small
number of available atomic resolution structures. We assessed the use of homology …

The growing number of studies on G protein-coupled receptors (GPCRs) family are a source
of noticeable improvement in our understanding of the functioning of these proteins. GPCRs …

Abstract GPCR-ModSim (http://open. gpcr-modsim. org) is a centralized and easy to use
service dedicated to the structural modeling of G-protein Coupled Receptors (GPCRs). 3D …

The determination of G protein-coupled receptor (GPCR) structures at atomic resolution has
improved understanding of cellular signaling and will accelerate the development of new …

The development of safe and effective drugs relies on the discovery of selective ligands.
Serotonin (5-hydroxytryptamine [5-HT]) G protein-coupled receptors are therapeutic targets …

G protein–coupled receptor (GPCR) structural biology has progressed dramatically in the
last decade. There are now over 120 GPCR crystal structures deposited in the Protein Data …

With> 800 members in humans, the G protein-coupled receptor (GPCR) super-family is the
target for more than 30% of the marketed drugs. The recent boom in GPCR crystallography …