Next-generation sequencing allows the analysis of genomes, including those representing
disease states. However, the causes of most disorders are multifactorial, and systems-level …

Abstract The PI3K (phosphatidylinositol 3-kinase)–AKT pathway is one of the most important
signaling networks in cancer. There is growing evidence that activation of this pathway plays …

Nonalcoholic fatty liver disease (NAFLD)–induced hepatocellular carcinoma (HCC) is an
emerging malignancy in the developed world; however, mechanisms that contribute to its …

Introduction: Stathmin is a microtubule-destabilizing phosphoprotein, firstly identified as the
downstream target of many signal transduction pathways. Several studies then indicated …

Acute myeloid leukemia (AML) is a heterogeneous disease with variable patient responses
to therapy. Selinexor, an inhibitor of nuclear export, has shown promising clinical activity for …

Background: The activity of the protein kinase Akt is frequently dysregulated in cancer and is
an important factor in the growth and survival of tumour cells. Akt activation involves the …

Background Brain metastases (BM) are a frequent complication of malignant melanoma
(MM), with limited treatment options and poor survival. Prevention of BM could be more …

The proline-rich Akt substrate of 40 kDa (PRAS40) acts at the intersection of the Akt-and
mammalian target of rapamycin (mTOR)-mediated signaling pathways. The protein kinase …

Immunohistochemistry-based clinical diagnoses require invasive core biopsies and use a
limited number of protein stains to identify and classify cancers. We introduce a technology …

The Yes-associated protein (YAP) is a transcriptional factor involved in tissue development
and tumorigenesis. Although YAP has been recognized as a key element of the Hippo …