The high concentration of mineral present in bone and pathological calcifications is unique
compared with all other tissues and thus provides opportunity for targeted delivery of …

Studies concerning the development of radiopharmaceuticals based on the Tc (I) carbonyl
core are considered from the coordination-chemical viewpoint. The coordination behavior of …

This article reviews Re and Tc organometallic chemistry and radiochemistry, focusing on the
most relevant aspects to design radiotools for molecular imaging and therapy. The review …

A high yield synthesis of a novel, small molecule, bisphosphonate-modified trans-
cyclooctene (TCO-BP, 2) that binds to regions of active bone metabolism and captures …

Bisphosphonates (BP's), biologically stable analogs of naturally occurring pyrophosphates,
became the treatment of choice for pathologic conditions characterized by increased …

The synthesis, stability, and photophysical properties of [2+ 1] Re (I)/Tc (I) complexes
derived from bipyridine and a series of imidazole derivatives were investigated as a means …

INTRODUCTION: Based on the concept of bifunctional radiopharmaceuticals, we have
previously developed 186Re-complex-conjugated bisphosphonate analogs for palliation of …

Growing interest in the biological activity of aminobisphosphonates has stimulated the
development of methods for their synthesis. Although several general procedures were …

68Ga (T 1/2= 68 min, a generator-produced nuclide) has great potential as a radionuclide
for clinical positron emission tomography (PET). Because poly-glutamic and poly-aspartic …

In recent years, the remarkable characteristics of the organometallic precursor fac-[M (CO) 3
(H 2 O) 3]+(M= Re, Tc) introduced by Alberto and co-workers brought renewed interest to the …