Immune check point blockade therapy has revolutionized the standard of cancer treatment
and is credited with producing remarkable tumor remissions and increase in overall survival …

Primary immunodeficiencies (PID) are disorders that for the most part result from mutations
in genes involved in immune host defense and immunoregulation. These conditions are …

Gliomas are brain tumors characterized by an immunosuppressive microenvironment.
Immunostimulatory agonistic CD40 antibodies (αCD40) are in clinical development for solid …

Chimeric antigen receptor (CAR) T cells provide great efficacy in B cell malignancies.
However, improved CAR T cell therapies are still needed. Here, we engineered tumor …

During the generation of a successful adaptive immune response, multiple molecular
signals are required. A primary signal is the binding of cognate antigen to an antigen …

The immune system is an organization of cells and molecules with specialized roles in
defending against infection. There are two fundamentally different types of responses to …

The physiological role of the TNF receptor (TNFR) family member, RANK, was investigated
by generating RANK-deficient mice. RANK−/− mice were characterized by profound …

Schistosomes are parasitic worms that are a prime example of a complex multicellular
pathogen that flourishes in the human host despite the development of a pronounced …

Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses,
including cell growth, differentiation, and even death. Here we describe a novel member of …

The cause of many autoimmune and inflammatory diseases is unresolved, although
dysregulated production of tumor necrosis factor (TNF) family members appears to be …