SUMMARY β-Lactam antibiotics have been widely used as therapeutic agents for the past
70 years, resulting in emergence of an abundance of β-lactam-inactivating β-lactamases …

A classification scheme for-lactamases based on functional characteristics is presented.
Three major groups of enzymes are defined by their substrate and inhibitor profiles: group 1 …

beta-Lactamases are the commonest single cause of bacterial resistance to beta-lactam
antibiotics. Numerous chromosomal and plasmid-mediated types are known and may be …

The biological diversity of the unicellular bacteria—whether assessed by shape, food,
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …

Although it is estimated that 20-30% of the general human population are carriers of
Staphylococcus aureus, this bacterium is one of the most important etiological agents …

The development of antibiotic resistance in Staphylococcus aureus, particularly in methicillin-
resistant S. aureus (MRSA), has become a significant health concern worldwide. The …

This review is intended to provide an overview of antimicrobial resistance in staphylococci.
Although we recently177 reviewed this topic in depth, the purpose of this article is to update …

Background Recent studies have favored the use of cefazolin over nafcillin for the treatment
of methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. The clinical influence …

Introduction β-Lactamases are some of the most prevalent and well-studied families of
enzymes, especially in the area of antibiotic resistance. Early attempts to categorize them …

Methicillin (meticillin)-susceptible Staphylococcus aureus (MSSA) strains producing large
amounts of type A β-lactamase (Bla) have been associated with cefazolin failures, but the …