Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Particulate matter (PM) is the principal component of air pollution. PM includes a range of
particle sizes, such as coarse, fine, and ultrafine particles. Particles that are< 100 nm in …

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)
syndrome is one of the most frequent maternally inherited mitochondrial disorders. MELAS …

Tobacco smoking is a major risk factor for cardiovascular disease and hypertension. It is
associated with the oxidative stress and induces metabolic reprogramming, altering …

Cigarette smoke (CS) causes considerable morbidity and mortality by inducing cancer,
chronic lung and vascular diseases, and oral disease. Despite the well-recognized risks …

Sirtuin 1 (SIRT1) is known to deacetylate histones and non-histone proteins including
transcription factors thereby regulating metabolism, stress resistance, cellular survival …

Mitochondria are a distinguishing feature of eukaryotic cells. Best known for their critical
function in energy production via oxidative phosphorylation (OXPHOS), mitochondria are …

Cigarette smoke (CS)-induced accumulation of mitochondrial damage has been widely
implicated in chronic obstructive pulmonary disease (COPD) pathogenesis. Mitophagy plays …

Background Cigarette smoking is the major risk factor for COPD, leading to chronic airway
inflammation. We hypothesized that cigarette smoke induces structural and functional …

Cigarette smoke (CS)-induced mitochondrial damage with increased reactive oxygen
species (ROS) production has been implicated in COPD pathogenesis by accelerating …