Microglia as a critical player in both developmental and late-life CNS pathologies

NC Derecki, N Katzmarski, J Kipnis… - Acta …, 2014 - Springer
Microglia, the tissue-resident macrophages of the brain, are attracting increasing attention
as key players in brain homeostasis from development through aging. Recent works have …

Virus‐based nanoparticles as platform technologies for modern vaccines

KL Lee, RM Twyman, S Fiering… - Wiley Interdisciplinary …, 2016 - Wiley Online Library
Nanoscale engineering is revolutionizing the development of vaccines and
immunotherapies. Viruses have played a key role in this field because they can function as …

Label-free imaging of amyloid plaques in Alzheimer's disease with stimulated Raman scattering microscopy

M Ji, M Arbel, L Zhang, CW Freudiger, SS Hou… - Science …, 2018 - science.org
One of the key pathological features of Alzheimer's disease (AD) is the existence of
extracellular deposition of amyloid plaques formed with misfolded amyloid-β (Aβ). The …

Advanced fiber soliton sources for nonlinear deep tissue imaging in biophotonics

K Wang, NG Horton, K Charan… - IEEE Journal of Selected …, 2013 - ieeexplore.ieee.org
Optical imaging plays a major role in both basic biological research and clinical diagnostics,
providing noninvasive or minimally invasive microscopic imaging capability to investigate …

Relationship between total phenolic contents and biological properties of propolis from 20 different regions in South Korea

X Wang, K Sankarapandian, Y Cheng, SO Woo… - … and alternative medicine, 2016 - Springer
Background Propolis (or bee glue), collected from botanical sources by honey bee, has
been used as a popular natural remedies in folk medicine throughout the world. This study …

Amyloid plaque formation precedes dendritic spine loss

T Bittner, S Burgold, MM Dorostkar, M Fuhrmann… - Acta …, 2012 - Springer
Amyloid-beta plaque deposition represents a major neuropathological hallmark of
Alzheimer's disease. While numerous studies have described dendritic spine loss in …

Micromotor-based localized electroporation and gene transfection of mammalian cells

Y Wu, A Fu, G Yossifon - Proceedings of the National …, 2021 - National Acad Sciences
Herein, we studied localized electroporation and gene transfection of mammalian cells
using a metallodielectric hybrid micromotor that is magnetically and electrically powered …

Long-term dynamics of aberrant neuronal activity in awake Alzheimer's disease transgenic mice

V Korzhova, P Marinković, JR Njavro… - Communications …, 2021 - nature.com
Alzheimer's disease (AD) is associated with aberrant neuronal activity, which is believed to
critically determine disease symptoms. How these activity alterations emerge, how stable …

[PDF][PDF] Pathogenesis of Alzheimer's disease: role of amyloid-beta and hyperphosphorylated tau protein

R Sajjad, R Arif, AA Shah, I Manzoor… - Indian J. Pharm. Sci, 2018 - academia.edu
The pathological emblems of Alzheimer's disease are the accumulation of amyloid-β
plaques and neurofibrillary tangles. The alluvium of toxic amyloid-β-protein in the form of …

Selective persistence of sensorimotor mismatch signals in visual cortex of behaving Alzheimer's disease mice

S Liebscher, GB Keller, PM Goltstein, T Bonhoeffer… - Current Biology, 2016 - cell.com
Neurodegenerative processes in Alzheimer's disease (AD) affect the structure and function
of neurons [1–4], resulting in altered neuronal activity patterns comprising neuronal hypo …