Among the determinants of atherosclerotic cardiovascular disease (ASCVD), genetic and
experimental evidence has provided data on a major role of angiopoietin-like proteins 3 and …

Lipoprotein lipase (LPL) is a rate-limiting enzyme that catalyzes hydrolysis of the triglyceride
(TG) core of circulating TG-rich lipoproteins including chylomicrons (CM), low-density …

Inhibition of immunocyte infiltration and activation has been suggested to effectively
ameliorate nonalcoholic steatohepatitis (NASH). Paired immunoglobulin-like receptor B …

Angiopoietin-like protein (ANGPTL) 8 has been implicated in metabolic syndrome and
reported to regulate adipose FA uptake through unknown mechanisms. Here, we studied …

Abstract Angiopoietin-like (ANGPTL) 3 and ANGPTL8 are secreted proteins and inhibitors of
LPL-mediated plasma triglyceride (TG) clearance. It is unclear how these two ANGPTL …

Angiopoietin-like (ANGPTL) 8 is a secreted inhibitor of LPL, a key enzyme in plasma
triglyceride metabolism. It was previously reported that ANGPTL8 requires another member …

Triglycerides (TG) are required for fatty acid transport and storage and are essential for
human health. Angiopoietin-like-protein 8 (ANGPTL8) has previously been shown to form a …

Excessive nuclear factor-κB (NF-κB) activation mediated by tumor necrosis factor α (TNFα)
plays a critical role in inflammation. Here we demonstrate that angiopoietin-like 8 …

ABSTRACT Introduction: Angiopoietin-like (ANGPTL) proteins belong to a family of eight
secreted factors that are structurally related to proteins that modulate angiogenesi …

Hypertriglyceridemia is a risk factor for a series of diseases, such as cardiovascular disease
(CVD), diabetes and nonalcoholic fatty liver disease (NAFLD). Angiopoietin-like proteins …