This document was written with the intent to be a complete reference at the time of
publication on the topic of managing hypertension in the elderly. Given the length of the …

The INTERSALT Study is a standardized, worldwide epidemiologic study of large sample
size (n= 10079 men and women aged 20–59 y from 32 countries) that tested both within-and …

Unlike sodium, potassium is vasoactive; for example, when infused into the arterial supply of
a vascular bed, blood flow increases. The vasodilation results from hyperpolarization of the …

In 1957 the American Heart Association proposed that modification of dietary fat intake
would reduce the incidence of coronary heart disease (CHD), which had become the …

The DASH Diet, Sodium Intake and Blood Pressure Trial (DASH-Sodium) is a multicenter,
randomized trial comparing the effects of 3 levels of sodium intake and 2 dietary patterns on …

Although the definitive cause of primary hypertension remains unknown, significant
advances have been made in understanding its pathogenesis and its clinical physiology …

Endogenous digitalis-like factors, also called cardiotonic steroids, have been thought for
nearly half a century to have important roles in health and disease. The endogenous …

The observational data relating salt and blood pressure (excluding INTERSALT) are
reviewed. Important methodological difficulties and biases are inherent to both across-and …

Eicosanoids are biologically active lipids in both physiologic and pathophysiologic
situations. These mediators rapidly generate at sites of inflammation and act through specific …

Diet may influence stroke risk via several mechanisms, but the optimal dietary habits for
stroke prevention are not well established. We reviewed English-language MEDLINE …