Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity …

SARS-CoV-2 infection is benign in most individuals but, in around 10% of cases, it triggers
hypoxaemic COVID-19 pneumonia, which leads to critical illness in around 3% of cases …

Children and adolescents exhibit a broad range of clinical outcomes from SARS-CoV-2
infection, with the majority having minimal to mild symptoms. Additionally, some succumb to …

Neutralizing autoantibodies against type I interferons (IFNs) have been found in some
patients with critical coronavirus disease 2019 (COVID-19), the disease caused by severe …

Recessive or dominant inborn errors of type I interferon (IFN) immunity can underlie critical
COVID-19 pneumonia in unvaccinated adults. The risk of COVID-19 pneumonia in …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR)
doubles with every 5 y of age from childhood onward. Circulating autoantibodies …

SARS-CoV-2 infection can cause severe respiratory COVID-19. However, many individuals
present with isolated upper respiratory symptoms, suggesting potential to constrain viral …

COVID-19 shares the feature of autoantibody production with systemic autoimmune
diseases. In order to understand the role of these immune globulins in the pathogenesis of …

SARS-CoV-2 infections mostly lead to mild or even asymptomatic infections in children, but
the reasons for this are not fully understood. More efficient local tissue responses, better …

Disease and accompanying inflammation are uncommon outcomes of viral infection in
humans. Clinical inflammation occurs if steady-state cell-intrinsic and leukocytic immunity to …