Chemical tools have proven indispensable for studies in glycobiology. Synthetic
oligosaccharides and glycoconjugates provide materials for correlating structure with …

Myriad biological communication events achieve the requisite level of specificity by
exploiting the rich structural and functional diversity of glycoconjugates. Although a wide …

Targeting of drugs and their carrier systems by using receptor-mediated endocytotic
pathways was in its nascent stages 25years ago. In the intervening years, an explosion of …

Cell‐surface receptors acquire information from the extracellular environment and
coordinate intracellular responses. Many receptors do not operate as individual entities, but …

Multivalent ligands can function as inhibitors or effectors of biological processes. Potent
inhibitory activity can arise from the high functional affinities of multivalent ligand− receptor …

Glycans are key participants in biological processes ranging from reproduction to cellular
communication to infection. Revealing glycan roles and the underlying molecular …

Processes such as cell–cell recognition and the initiation of signal transduction often
depend on the formation of multiple receptor-ligand complexes at the cell surface. Synthetic …

Recent progress in glycobiology has revealed that cell surface oligosaccharides play an
essential role in recognition events. More precisely, these saccharides may be complexed …

Multivalency is a powerful and versatile self-assembly pathway that confers unique
thermodynamic and kinetic behavior onto supramolecular complexes. The diversity of the …

Background The most demanding challenge in research on molecular aspects within the
flow of biological information is posed by the complex carbohydrates (glycan part of cellular …