Fatty acid transport and signaling: mechanisms and physiological implications

D Samovski, M Jacome-Sosa… - Annual review of …, 2023 - annualreviews.org
Long-chain fatty acids (FAs) are components of plasma membranes and an efficient fuel
source and also serve as metabolic regulators through FA signaling mediated by membrane …

Gut microbiota‐derived lipopolysaccharide uptake and trafficking to adipose tissue: implications for inflammation and obesity

LG Hersoug, P Møller, S Loft - Obesity Reviews, 2016 - Wiley Online Library
The composition of the gut microbiota and excessive ingestion of high‐fat diets (HFD) are
considered to be important factors for development of obesity. In this review we describe a …

The metabolic impact of small intestinal nutrient sensing

FA Duca, TMZ Waise, WT Peppler, TKT Lam - Nature communications, 2021 - nature.com
The gastrointestinal tract maintains energy and glucose homeostasis, in part through
nutrient-sensing and subsequent signaling to the brain and other tissues. In this review, we …

Structure-function of CD36 and importance of fatty acid signal transduction in fat metabolism

MY Pepino, O Kuda, D Samovski… - Annual review of …, 2014 - annualreviews.org
CD36 (cluster of differentiation 36) is a scavenger receptor that functions in high-affinity
tissue uptake of long-chain fatty acids (FAs) and contributes under excessive fat supply to …

The role of CD36 in cardiovascular disease

H Shu, Y Peng, W Hang, J Nie, N Zhou… - Cardiovascular …, 2022 - academic.oup.com
CD36, also known as the scavenger receptor B2, is a multifunctional receptor widely
expressed in various organs. CD36 plays a crucial role in the uptake of long-chain fatty …

[HTML][HTML] Taste of fat: a sixth taste modality?

P Besnard, P Passilly-Degrace… - Physiological …, 2015 - journals.physiology.org
An attraction for palatable foods rich in lipids is shared by rodents and humans. Over the last
decade, the mechanisms responsible for this specific eating behavior have been actively …

Intestinal alkaline phosphatase: novel functions and protective effects

JP Lallès - Nutrition reviews, 2014 - academic.oup.com
Important protective roles of intestinal alkaline phosphatase (IAP)–including regulation of
intestinal surface pH, absorption of lipids, detoxification of free nucleotides and bacterial …

The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9

R Beatson, V Tajadura-Ortega, D Achkova, G Picco… - Nature …, 2016 - nature.com
Siglec-9 is a sialic-acid-binding lectin expressed predominantly on myeloid cells. Aberrant
glycosylation occurs in essentially all types of cancers and results in increased sialylation …

Role of the gut in lipid homeostasis

NA Abumrad, NO Davidson - Physiological reviews, 2012 - journals.physiology.org
Intestinal lipid transport plays a central role in fat homeostasis. Here we review the pathways
regulating intestinal absorption and delivery of dietary and biliary lipid substrates, principally …

PCSK9 induces CD36 degradation and affects long-chain fatty acid uptake and triglyceride metabolism in adipocytes and in mouse liver

A Demers, S Samami, B Lauzier… - … , and vascular biology, 2015 - Am Heart Assoc
Objective—Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes the degradation
of the low-density lipoprotein receptor thereby elevating plasma low-density lipoprotein …