Targeting DEAD‐box RNA helicases: The emergence of molecular staples
RNA helicases constitute a large family of proteins that play critical roles in mediating RNA
function. They have been implicated in all facets of gene expression pathways involving …
function. They have been implicated in all facets of gene expression pathways involving …
Steroid and triterpenoid compounds with antiparasitic properties
IZ Kuzminac, MP Savić, JJ Ajduković… - Current Topics in …, 2023 - benthamdirect.com
Parasitic diseases affect millions of people and animals, predominantly in the tropics,
including visitors to tropical countries and other areas. Efficient and low-cost treatments for …
including visitors to tropical countries and other areas. Efficient and low-cost treatments for …
A comparative study of small molecules targeting eIF4A
The PI3K/Akt/mTOR kinase pathway is extensively deregulated in human cancers. One
critical node under regulation of this signaling axis is eukaryotic initiation factor (eIF) 4F, a …
critical node under regulation of this signaling axis is eukaryotic initiation factor (eIF) 4F, a …
Selective targeting of the DEAD-box RNA helicase eukaryotic initiation factor (eIF) 4A by natural products
L Shen, J Pelletier - Natural product reports, 2020 - pubs.rsc.org
Covering: up to 2019 Pharmacological targeting of eukaryotic mRNA translation initiation is
a promising approach for cancer therapy, since several signaling pathways that are …
a promising approach for cancer therapy, since several signaling pathways that are …
Targeting the DEAD-box RNA helicase eIF4A with rocaglates—a pan-antiviral strategy for minimizing the impact of future RNA virus pandemics
G Taroncher-Oldenburg, C Müller, W Obermann… - Microorganisms, 2021 - mdpi.com
The increase in pandemics caused by RNA viruses of zoonotic origin highlights the urgent
need for broad-spectrum antivirals against novel and re-emerging RNA viruses. Broad …
need for broad-spectrum antivirals against novel and re-emerging RNA viruses. Broad …
Novel eIF4A1 inhibitors with anti‐tumor activity in lymphoma
F Kayastha, NB Herrington, B Kapadia… - Molecular …, 2022 - Springer
Background Deregulated translation initiation is implicated extensively in cancer initiation
and progression. It is actively pursued as a viable target that circumvents the dependency on …
and progression. It is actively pursued as a viable target that circumvents the dependency on …
Translational profiling of macrophages infected with Leishmania donovani identifies mTOR- and eIF4A-sensitive immune-related transcripts
V Chaparro, LP Leroux, L Masvidal, J Lorent… - PLoS …, 2020 - journals.plos.org
The protozoan parasite Leishmania donovani (L. donovani) causes visceral leishmaniasis, a
chronic infection which is fatal when untreated. Herein, we investigated whether in addition …
chronic infection which is fatal when untreated. Herein, we investigated whether in addition …
NHX1 and eIF4A1-stacked transgenic sweetpotato shows enhanced tolerance to drought stress
Key message Co-expression of Na+/H+ antiporter NHX1 and DEAD-box RNA helicase
eIF4A1 from Arabidopsis positively regulates drought stress tolerance by improving ROS …
eIF4A1 from Arabidopsis positively regulates drought stress tolerance by improving ROS …
Happy birthday: 30 years of RNA helicases
M Valentini, P Linder - RNA Remodeling Proteins: Methods and Protocols, 2021 - Springer
RNA helicases are ubiquitous, highly conserved RNA-binding enzymes that use the energy
derived from the hydrolysis of nucleoside triphosphate to modify the structure of RNA …
derived from the hydrolysis of nucleoside triphosphate to modify the structure of RNA …
Known inhibitors of RNA helicases and their therapeutic potential
YZ Abdelkrim, J Banroques, N Kyle Tanner - RNA Remodeling Proteins …, 2020 - Springer
RNA helicases are proteins found in all kingdoms of life, and they are associated with all
processes involving RNA from transcription to decay. They use NTP binding and hydrolysis …
processes involving RNA from transcription to decay. They use NTP binding and hydrolysis …