Thermostability is considered to be an important parameter to measure the feasibility of
enzymes for industrial applications. Generally, higher thermostability makes an enzyme …

During the past 15 years there has been a continuous flow of reports describing proteins
stabilized by the introduction of mutations. These reports span a period from pioneering …

The refinement and validation of a crystallographic structure model is the last step before the
coordinates and the associated data are submitted to the Protein Data Bank (PDB). The …

Comparative protein structure modeling predicts the three‐dimensional structure of a given
protein sequence (target) based primarily on its alignment to one or more proteins of known …

Protein side-chain packing (PSCP), the task of determining amino acid side-chain
conformations given only backbone atom positions, has important applications to protein …

We have developed a computer algorithm, FOLDEF (for FOLD-X energy function), to provide
a fast and quantitative estimation of the importance of the interactions contributing to the …

We present a Bayesian statistical analysis of the conformations of side chains in proteins
from the Protein Data Bank. This is an extension of the backbone‐dependent rotamer library …

EEC syndrome is an autosomal dominant disorder characterized by ectrodactyly,
ectodermal dysplasia, and facial clefts. We have mapped the genetic defect in several EEC …

We describe a new approach, based on the energy of non-local interactions, to assess
protein structures. The method uses a very sensitive and accurate atomic mean force …

Proteins play a critical role in carrying out biological functions, and their 3D structures are
essential in determining their functions. Accurately predicting the conformation of protein …