Migraine is a primary headache disorder characterized by a unilateral, throbbing, pulsing
headache, which lasts for hours to days, and the pain can interfere with daily activities. It …

Over the past 300 years, the migraine field has been dominated by two main theories—the
vascular theory and the central neuronal theory. The success of vasoconstrictors such as …

Introduction The trigeminal ganglion is unique among the somatosensory ganglia regarding
its topography, structure, composition and possibly some functional properties of its cellular …

The trigeminal ganglion with its three trigeminal nerve tracts consists mainly of clusters of
sensory neurons with their peripheral and central processes. Most neurons are surrounded …

Neurogenic inflammation, a well-defined pathophysiologial process is characterized by the
release of potent vasoactive neuropeptides, predominantly calcitonin gene-related peptide …

Calcitonin gene-related peptide (CGRP) and/or substance P (SP) immunoreactivity as well
as isolectin B4 (IB4) binding are commonly used to define peptidergic and non-peptidergic …

Calcitonin-gene-related peptide (CGRP), a potent vasodilator that mediates inflammatory
pain, is elevated in migraine; nevertheless, little is known about its release from sensory …

Historically, drug research targeted to pain treatment has focused on trying to prevent the
propagation of action potentials in the periphery from reaching the brain rather than …

Objective To perform a meta-analysis of migraine biomarkers in cerebrospinal fluid (CSF)
and of corresponding blood concentrations. Methods We conducted a systematic search for …

Current treatments of injured peripheral nerves often fail to mediate satisfactory functional
recovery. For axonal regeneration, neurotrophic factors (NTFs) play a crucial role. Multiple …