Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …

This review fully describes the coronavirus 3CL pro peptidomimetic inhibitors and
nonpeptidic small molecule inhibitors developed from 2010 to 2020. Specifically, the …

Isatin (1H-indole-2, 3-dione) and its derivatives represent an important class of heterocyclic
compounds that can be used as precursors for drug synthesis. Since its discovery, a lot of …

The current work aims to design and synthesis a new series of isatin derivatives and greatly
enhances their cytotoxic activity. The derivatives 3-((bromophenyl) imino)-1-(morpholino …

Ribonucleases (RNases) cleave and process RNAs, thereby regulating the biogenesis,
metabolism, and degradation of coding and noncoding RNAs. Thus, small molecules …

Thiazoles and their hydrogenated analogues are not only key structural units in a wide
variety of natural products but they also constitute important building blocks in medicinal …

Human immunodeficiency virus (HIV) especially HIV-1 infection and its progression to
acquired immune deficiency syndrome (AIDS) remains a significant global health challenge …

During HIV-1 genome replication, the viral reverse transcriptase-associated ribonuclease H
(RT-associated RNase H) activity hydrolyzes the RNA strand of RNA/DNA heteroduplex …

Abstract Ribonucleases H (RNases H) are endonucleolytic enzymes, evolutionarily related
to retroviral integrases, DNA transposases, resolvases and numerous nucleases. RNases H …

Dimerization is a promising strategy to develop novel drug candidates that could extend the
biological spectrum, enhance the activity, overcome drug resistance, as well as improve …