A review of data mining using big data in health informatics
M Herland, TM Khoshgoftaar, R Wald - Journal of Big data, 2014 - Springer
The amount of data produced within Health Informatics has grown to be quite vast, and
analysis of this Big Data grants potentially limitless possibilities for knowledge to be gained …
analysis of this Big Data grants potentially limitless possibilities for knowledge to be gained …
[HTML][HTML] Molecular and cellular heterogeneity in breast cancer: challenges for personalized medicine
AG Rivenbark, SM O'Connor, WB Coleman - The American journal of …, 2013 - Elsevier
Breast cancer is noted for disparate clinical behaviors and patient outcomes, despite
common histopathological features at diagnosis. Molecular pathogenesis studies suggest …
common histopathological features at diagnosis. Molecular pathogenesis studies suggest …
Effect of pembrolizumab plus neoadjuvant chemotherapy on pathologic complete response in women with early-stage breast cancer: an analysis of the ongoing …
Importance Approximately 25% of patients with early-stage breast cancer who receive (neo)
adjuvant chemotherapy experience a recurrence within 5 years. Improvements in therapy …
adjuvant chemotherapy experience a recurrence within 5 years. Improvements in therapy …
[HTML][HTML] Adaptive randomization of veliparib–carboplatin treatment in breast cancer
HS Rugo, OI Olopade, A DeMichele… - … England Journal of …, 2016 - Mass Medical Soc
Background The genetic and clinical heterogeneity of breast cancer makes the identification
of effective therapies challenging. We designed I-SPY 2, a phase 2, multicenter, adaptively …
of effective therapies challenging. We designed I-SPY 2, a phase 2, multicenter, adaptively …
[HTML][HTML] Adaptive randomization of neratinib in early breast cancer
JW Park, MC Liu, D Yee, C Yau… - … England Journal of …, 2016 - Mass Medical Soc
Background The heterogeneity of breast cancer makes identifying effective therapies
challenging. The I-SPY 2 trial, a multicenter, adaptive phase 2 trial of neoadjuvant therapy …
challenging. The I-SPY 2 trial, a multicenter, adaptive phase 2 trial of neoadjuvant therapy …
A comparison of PAM50 intrinsic subtyping with immunohistochemistry and clinical prognostic factors in tamoxifen-treated estrogen receptor–positive breast cancer
Purpose: To compare clinical, immunohistochemical (IHC), and gene expression models of
prognosis applicable to formalin-fixed, paraffin-embedded blocks in a large series of …
prognosis applicable to formalin-fixed, paraffin-embedded blocks in a large series of …
Tumor microenvironment complexity: emerging roles in cancer therapy
The tumor microenvironment (TME) consists of cells, soluble factors, signaling molecules,
extracellular matrix, and mechanical cues that can promote neoplastic transformation …
extracellular matrix, and mechanical cues that can promote neoplastic transformation …
Stromal gene expression predicts clinical outcome in breast cancer
Although it is increasingly evident that cancer is influenced by signals emanating from tumor
stroma, little is known regarding how changes in stromal gene expression affect epithelial …
stroma, little is known regarding how changes in stromal gene expression affect epithelial …
Gene expression signature to improve prognosis prediction of stage II and III colorectal cancer
Purpose This study aims to develop a robust gene expression classifier that can predict
disease relapse in patients with early-stage colorectal cancer (CRC). Patients and Methods …
disease relapse in patients with early-stage colorectal cancer (CRC). Patients and Methods …
A comprehensive comparison of random forests and support vector machines for microarray-based cancer classification
A Statnikov, L Wang, CF Aliferis - BMC bioinformatics, 2008 - Springer
Background Cancer diagnosis and clinical outcome prediction are among the most
important emerging applications of gene expression microarray technology with several …
important emerging applications of gene expression microarray technology with several …