Macromolecular crowding: Sensing without a sensor

LJ Holt, M Delarue - Current Opinion in Cell Biology, 2023 - Elsevier
All living cells are crowded with macromolecules. Crowding can directly modulate
biochemical reactions to various degrees depending on the sizes, shapes, and binding …

Role of J-domain proteins in yeast physiology and protein quality control

C Ruger-Herreros, L Svoboda, A Mogk… - Journal of Molecular …, 2024 - Elsevier
The Hsp70 chaperone system is a central component of cellular protein quality control
(PQC) by acting in a multitude of protein folding processes ranging from the folding of newly …

Biomolecular condensates–extant relics or evolving microcompartments?

V Rangachari - Communications Biology, 2023 - nature.com
Unprecedented discoveries during the past decade have unearthed the ubiquitous
presence of biomolecular condensates (BCs) in diverse organisms and their involvement in …

Structure and interactions of prion-like domains in transcription factor Efg1 phase separation

SH Wang, T Zheng, NL Fawzi - Biophysical Journal, 2024 - cell.com
Candida albicans, a prominent member of the human microbiome, can make an
opportunistic switch from commensal coexistence to pathogenicity accompanied by an …

SNARE protein Snc1 is essential for vesicle trafficking, membrane fusion and protein secretion in fungi

M Adnan, W Islam, A Waheed, Q Hussain, L Shen… - Cells, 2023 - mdpi.com
Fungi are an important group of microorganisms that play crucial roles in a variety of
ecological and biotechnological processes. Fungi depend on intracellular protein trafficking …

Filamentation and biofilm formation are regulated by the phase-separation capacity of network transcription factors in Candida albicans

C Ganser, MI Staples, M Dowell, C Frazer… - Plos …, 2023 - journals.plos.org
The ability of the fungus Candida albicans to filament and form biofilms contributes to its
burden as a leading cause of hospital-acquired infections. Biofilm development involves an …

Emerging Functional Porous Scaffolds for Liver Tissue Engineering

J Wang, D Huang, D Chen, H Ren… - Advanced Healthcare …, 2024 - Wiley Online Library
Liver tissue engineering holds promising in synthesizing or regenerating livers, while the
design of functional scaffold remains a challenge. Owing to the intricate simulation of …

Alternative isoforms and phase separation of Ref1 repress morphogenesis in Cryptococcus

NK Glueck, X Xie, X Lin - Cell reports, 2024 - cell.com
Cryptococcus neoformans, the causative agent of cryptococcosis and a representative of the
Basidiomycota phylum of Fungi, is a valuable model for our understanding of …

Spatiotemporal Organization of Functional Cargoes by Light-Switchable Condensation in Escherichia coli Cells

F Pan, H Zu, YJ Zhu, ZG Qian, XX Xia - JACS Au, 2024 - ACS Publications
Biomolecular condensates are dynamic subcellular compartments that lack surrounding
membranes and can spatiotemporally organize the cellular biochemistry of eukaryotic cells …

Self-limiting Selective Phase Separation of Graphene Oxide and Polymer Composites Solution

F Chen, L Wang, K Li, R Guo, Y Qin, C Shen, Y Liu… - Nanoscale, 2025 - pubs.rsc.org
Homogeneous mixtures undergo phase separation to generate rich heterogeneous
structures and enable complex physiological activity and delicate design of artificial …