CD4 T cells play critical roles in mediating adaptive immunity to a variety of pathogens. They
are also involved in autoimmunity, asthma, and allergic responses as well as in tumor …

Abstract Interferon‐γ (IFN‐γ) is crucial for immunity against intracellular pathogens and for
tumor control. However, aberrant IFN‐γ expression has been associated with a number of …

Summary Mapping DNase I hypersensitive (HS) sites is an accurate method of identifying
the location of genetic regulatory elements, including promoters, enhancers, silencers …

Since the discovery of the first nuclear factor of activated T cells (NFAT) protein more than a
decade ago, the NFAT family of transcription factors has grown to include five members. It …

CD4+ T cells, also known as T‐helper (Th) cells, play an important role in orchestrating
adaptive immune responses to various infectious agents. They are also involved in the …

Antigen stimulation of immune cells activates the transcription factor NFAT, a key regulator of
T cell activation and anergy. NFAT forms cooperative complexes with the AP-1 family of …

Naive CD4+ T cells give rise to T-helper-cell subsets with functions that are tailored to their
respective roles in host defence. The specification of T-helper-cell subsets is controlled by …

T-bet and GATA3 regulate the CD4+ T cell Th1/Th2 cell fate decision but little is known
about the interplay between these factors outside of the murine Ifng and Il4/Il5/Il13 loci. Here …

The nuclear factor of activated T cells (NFAT) family of transcription factors, which includes
NFAT1, NFAT2, and NFAT4, are well-known to play important roles in T cell activation. Most …

Cell differentiation involves activation and silencing of lineage-specific genes. Here we
show that the transcription factor Runx3 is induced in T helper type 1 (TH1) cells in a T-bet …