Invading cancer cells adapt their migration phenotype in response to mechanical and
biochemical cues from the extracellular matrix. For instance, mesenchymal migration is …

Conventional 2D cell culture, a traditional tool in pre-clinical studies, can hardly be regarded
as a representation of a natural cell microenvironment. In this respect, it might result in …

Tumors and the tumor microenvironment produce multiple growth factors that influence
cancer cell behavior via various signal transduction pathways. Growth factors, like …

Chemotactic cell migration is a central mechanism during cancer cell invasion and hence
metastasis. In order to mimic in vivo conditions, we used a three-dimensional hydrogel …

As cells migrate through biological tissues, they must frequently squeeze through micron-
sized constrictions in the form of interstitial pores between extracellular matrix fibers and/or …

One of the hallmarks of cancer cells is their exceptional ability to migrate within the
extracellular matrix (ECM) for gaining access to the circulatory system, a critical step of …

Epidermal growth factor (EGF), a potent cytokine, is known to promote tumor invasion both in
vivo and in vitro. Previously, we observed that single breast tumor cells (MDA-MB-231 cell …

Understanding how extracellular matrix (ECM) stiffness and biochemical factors such as
TGF-β affect cell behaviour is critical for elucidating mechanisms underlying several …

The epidermal growth factor (EGF) plays a key role in physiological and pathological
processes. This work reports on the influence of EGF concentration (c EGF) on the …

Cells interact with the extracellular matrix (ECM) mechanically to perform essential cell
function including migration, proliferation and differentiation, which are critical in …