Pupillometry as an integrated readout of distinct attentional networks
The course of pupillary constriction and dilation provides an easy-to-access, inexpensive,
and noninvasive readout of brain activity. We propose a new taxonomy of factors affecting …
and noninvasive readout of brain activity. We propose a new taxonomy of factors affecting …
Pupil size as a window on neural substrates of cognition
Cognitively driven pupil modulations reflect certain underlying brain functions. What do
these reflections tell us? Here, we review findings that have identified key roles for three …
these reflections tell us? Here, we review findings that have identified key roles for three …
Norepinephrine links astrocytic activity to regulation of cortical state
Cortical state, defined by population-level neuronal activity patterns, determines sensory
perception. While arousal-associated neuromodulators—including norepinephrine (NE) …
perception. While arousal-associated neuromodulators—including norepinephrine (NE) …
Freezing revisited: coordinated autonomic and central optimization of threat coping
K Roelofs, P Dayan - Nature Reviews Neuroscience, 2022 - nature.com
Animals have sophisticated mechanisms for coping with danger. Freezing is a unique state
that, upon threat detection, allows evidence to be gathered, response possibilities to be …
that, upon threat detection, allows evidence to be gathered, response possibilities to be …
[HTML][HTML] Rapid reconfiguration of the functional connectome after chemogenetic locus coeruleus activation
The locus coeruleus (LC) supplies norepinephrine (NE) to the entire forebrain and regulates
many fundamental brain functions. Studies in humans have suggested that strong LC …
many fundamental brain functions. Studies in humans have suggested that strong LC …
Transcutaneous vagus nerve stimulation in humans induces pupil dilation and attenuates alpha oscillations
Vagus nerve stimulation (VNS) is widely used to treat drug-resistant epilepsy and
depression. While the precise mechanisms mediating its long-term therapeutic effects are …
depression. While the precise mechanisms mediating its long-term therapeutic effects are …
Noradrenergic modulation of rhythmic neural activity shapes selective attention
During moments involving selective attention, the thalamus orchestrates the preferential
processing of prioritized information by coordinating rhythmic neural activity within a …
processing of prioritized information by coordinating rhythmic neural activity within a …
Locus coeruleus norepinephrine activity mediates sensory-evoked awakenings from sleep
H Hayat, N Regev, N Matosevich, A Sales… - Science …, 2020 - science.org
A defining feature of sleep is reduced responsiveness to external stimuli, but the
mechanisms mediating sensory-evoked arousal remain unclear. We hypothesized that …
mechanisms mediating sensory-evoked arousal remain unclear. We hypothesized that …
The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity
Prediction errors are differences between expected and actual sensory input and are
thought to be key computational signals that drive learning related plasticity. One way that …
thought to be key computational signals that drive learning related plasticity. One way that …
High-speed volumetric two-photon fluorescence imaging of neurovascular dynamics
Understanding the structure and function of vasculature in the brain requires us to monitor
distributed hemodynamics at high spatial and temporal resolution in three-dimensional (3D) …
distributed hemodynamics at high spatial and temporal resolution in three-dimensional (3D) …