Bone infection is a devastating disease characterized by recurrence, drug-resistance, and
high morbidity, that has prompted clinicians and scientists to develop novel approaches to …

Autologous bone grafting is currently considered as the gold standard to restore bone
defects. However, clinical benefit is not guaranteed and there is an associated 8–39 …

In the last 15 years, a large number of commercial ceramicbased cements and putties have
been introduced as bone graft substitutes. As a result, large efforts have been made to …

Objectives: We sought to compare the effectiveness of an antibiotic-impregnated
bioabsorbable bone substitute (BBS, tobramycin-impregnated medical-grade calcium …

Local release of antibiotic has advantages in the treatment of chronic osteomyelitis and
infected fractures. The adequacy of surgical debridement is still key to successful clearance …

Calcium sulfate as a bone graft substitute is rapidly resorbed in vivo releasing calcium ions
but fails to provide long-term three-dimensional framework to support osteoconduction. The …

Calcium phosphates (CaPO 4) and faster-resorbing calcium sulfate (CaSO 4) are
successfully employed as synthetic bone grafts for treatment of contained defects. We used …

We asked if tobramycin-loaded calcium sulfate pellets could be used to maintain high local
site antibiotic concentrations for an extended period with minimal systemic levels and …

Objective Local antibiotic delivery systems with differing chemical and mechanical
properties have been developed to assist in the management of osteomyelitis. We …

Local antibiotic use began more than 100 years ago with Joseph Lister, who pioneered safe,
antiseptic surgery. Before Lister's innovations, as many as 80% of all operations were …