To pass on genetic information to the next generation, cells must faithfully replicate their
genomes to provide copies for each daughter cell. To synthesise these duplicates, cells …

DNA replication in eukaryotes relies on the synthesis of a∼ 30-nucleotide RNA/DNA primer
strand through the dual action of the heterotetrameric polymerase α-primase (pol-prim) …

Eukaryotic DNA replication depends on the primosome–a complex of DNA polymerase
alpha (Pol α) and primase–to initiate DNA synthesis by polymerisation of an RNA–DNA …

Deficiencies in replication-coupled (RC) nucleosome assembly often lead to reduced DNA
replication rate, but the precise mechanism underlying this process remains unsolved. Here …

Telomeres at the end of eukaryotic chromosomes are extended by a specialized set of
enzymes and telomere-associated proteins, collectively termed here the telomere …

Members of the 3'-5'RNA polymerase family, comprised of tRNAHis guanylyltransferase
(Thg1) and Thg1-like proteins (TLPs), catalyze templated synthesis of RNA in the reverse …

DNA replication is a fundamental process by which organisms duplicate their DNA.
Accordingly, cells have evolved mechanisms to replicate their genome and safeguard it from …

The ubiquitin-proteasome system is an essential cellular instrument that provides timely
degradation of specific protein substrates. This thesis examines its role in the regulation of …