Penile squamous cell carcinoma (PSCC) is a rare cancer with orphan disease designation
and a prevalence of 0.1–1 per 100,000 men in high-income countries, but it constitutes up to …

Real-time intraoperative guidance is essential during oncological surgery for complete and
safe tumour resection. Fluorescence imaging in the near-infrared spectrum has shown …

Paradigm shifts in surgery arise when surgeons are empowered to perform surgery faster,
better and less expensively than current standards. Optical imaging that exploits invisible …

During the last decades, a plethora of nanoparticles have been developed and evaluated
and a real hype has been created around their potential application as diagnostic and …

Surgical resection is the primary and most effective treatment for most patients with solid
tumors. However, patients suffer from postoperative recurrence and metastasis. In the past …

Purpose Hybrid image-guided surgery technologies such as combined radio-and
fluorescence-guidance are increasingly gaining interest, but their added value still needs to …

Background Sentinel node (SN) biopsy in penile cancer (PeCa) is typically performed using
99m Tc-nanocolloid and blue dye. Recent reports suggested that the hybrid (radioactive and …

Indocyanine green (ICG) is a cyanine compound that displays fluorescent properties in the
near infrared region. This dye is employed for numerous indications but nowadays its major …

Recent developments and improvements of multimodal imaging methods for use in animal
research have substantially strengthened the options of in vivo visualization of cancer …

Medical imaging plays a critical role in cancer diagnosis and planning. Many of these
patients rely on surgical intervention for curative outcomes. This requires a careful …