Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

ABSTRACT The α1β1, α2β1, α10β1 and α11β1 integrins constitute a subset of the integrin
family with affinity for GFOGER-like sequences in collagens. Integrins α1β1 and α2β1 were …

Hypertrophic differentiation is not only the terminal process of endochondral ossification in
the growth plate but is also an important pathological change in osteoarthritic cartilage …

Background: Cartilage tissue engineering (CTE) aims to obtain a structure mimicking native
cartilage tissue through the combination of relevant cells, three-dimensional scaffolds, and …

The integrin family of cell adhesion receptors plays a major role in mediating interactions
between cells and the extracellular matrix. Normal adult articular chondrocytes express …

Integrins are adhesion receptors that allow cells to sense and respond to
microenvironmental signals encoded by the extracellular matrix. They are crucial for the …

Osteoarthritis is often a progressive and disabling disease, which occurs in the setting of a
variety of risk factors–such as advancing age, obesity, and trauma–that conspire to incite a …

Osteoarthritis is characterized by a progressive degradation of articular cartilage leading to
loss of joint function. The molecular mechanisms regulating pathogenesis and progression …

The collagen family of extracellular matrix proteins has played a fundamental role in the
evolution of multicellular animals. At the present, 28 triple helical proteins have been named …

Cancers are complex ecosystems composed of malignant cells embedded in an intricate
microenvironment made of different non-transformed cell types and extracellular matrix …