[HTML][HTML] Inflammation-mediated tissue damage in pulmonary tuberculosis and host-directed therapeutic strategies

D Tiwari, AR Martineau - Seminars in Immunology, 2023 - Elsevier
Abstract Treatment of tuberculosis (TB) involves the administration of anti-mycobacterial
drugs for several months. The emergence of drug-resistant strains of Mycobacterium …

Glucose metabolism disorder: a potential accomplice of SARS-CoV-2

Y Luan, Y Luan, H He, B Jue, Y Yang, B Qin… - International Journal of …, 2023 - nature.com
Abstract Globally, 265,713,467 confirmed cases of SARS-CoV-2 (CoV-2), including
5,260,888 deaths, have been reported by the WHO. It is important to study the mechanism of …

Metformin for treatment of acute COVID-19: systematic review of clinical trial data against SARS-CoV-2

SM Erickson, SL Fenno, N Barzilai, G Kuchel… - Diabetes …, 2023 - Am Diabetes Assoc
BACKGROUND Observational and preclinical data suggest metformin may prevent severe
coronavirus disease 2019 (COVID-19) outcomes. PURPOSE We conducted a systematic …

[HTML][HTML] COVID-19 associated liver injury: an updated review on the mechanisms and management of risk groups

Y Shi, M Wang, L Wu, X Li, Z Liao - Liver Research, 2023 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) has been associated with various liver
injury cases worldwide. To date, the prevalence, mechanism, clinical manifestations …

Unveiling the potential pleiotropic effects of metformin in treating COVID-19: A comprehensive review

P Petakh, I Kamyshna, A Kamyshnyi - Frontiers in Molecular …, 2023 - frontiersin.org
This review article explores the potential of metformin, a medication commonly used for type
2 diabetes, as an antiviral and anti-inflammatory agent in the context of coronavirus disease …

[HTML][HTML] SARS-CoV-2 receptor ACE2 is upregulated by fatty acids in human MASH

L Cano, L Desquilles, G Ghukasyan, G Angenard… - JHEP Reports, 2024 - Elsevier
Background & Aims Metabolic dysfunction-associated steatotic liver disease (MASLD)
results in steatosis, inflammation (steatohepatitis), and fibrosis. Patients with MASLD more …

Hepatic effects of acetochlor chiral isomers in zebrafish and L02 cells

X Wang, B Peng, C Zhang, M Wu, W Xu… - Science of The Total …, 2024 - Elsevier
The pesticide acetochlor (ACT) is a chiral isomer commonly detected in the global
environment, yet its specific impacts on liver function remain poorly understood. We utilized …

Spike protein impairs mitochondrial function in human cardiomyocytes: mechanisms underlying cardiac injury in COVID-19

TV Huynh, L Rethi, TW Lee, S Higa, YH Kao, YJ Chen - Cells, 2023 - mdpi.com
Background: COVID-19 has a major impact on cardiovascular diseases and may lead to
myocarditis or cardiac failure. The clove-like spike (S) protein of SARS-CoV-2 facilitates its …

Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes

X Yang, X Zheng, Y Zhu, X Zhao, J Liu, J Xun… - … and Targeted Therapy, 2024 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes multi-organ
damage, which includes hepatic dysfunction, as observed in over 50% of COVID-19 …

[HTML][HTML] SARS-CoV-2 and chronic hepatitis B: Focusing on the possible consequences of co-infection

S Shoraka, SR Mohebbi, SM Hosseini… - Journal of Clinical …, 2023 - Elsevier
The pandemic of 2019 coronavirus disease (COVID-19) has become a world public health
challenge. A new member of Coronaviridae family, named severe acute respiratory …