The physics of cell-size regulation across timescales
The size of a cell is determined by a combination of synthesis, self-assembly, incoming
matter and the balance of mechanical forces. Such processes operate at the single-cell …
matter and the balance of mechanical forces. Such processes operate at the single-cell …
The importance of water and hydraulic pressure in cell dynamics
All mammalian cells live in the aqueous medium, yet for many cell biologists, water is a
passive arena in which proteins are the leading players that carry out essential biological …
passive arena in which proteins are the leading players that carry out essential biological …
Extracellular matrix in multicellular aggregates acts as a pressure sensor controlling cell proliferation and motility
Imposed deformations play an important role in morphogenesis and tissue homeostasis,
both in normal and pathological conditions. To perceive mechanical perturbations of …
both in normal and pathological conditions. To perceive mechanical perturbations of …
Cellular mechanosensing of the biophysical microenvironment: a review of mathematical models of biophysical regulation of cell responses
Cells in vivo reside within complex microenvironments composed of both biochemical and
biophysical cues. The dynamic feedback between cells and their microenvironments hinges …
biophysical cues. The dynamic feedback between cells and their microenvironments hinges …
Controlling cellular volume via mechanical and physical properties of substrate
The mechanical and physical properties of substrate play a crucial role in regulating many
cell functions and behaviors. However, how these properties affect cell volume is still …
cell functions and behaviors. However, how these properties affect cell volume is still …
Cell mechanical microenvironment for cell volume regulation
Cell volume regulation, as one of the fundamental homeostasis of the cell, is associated with
many cellular behaviors and functions. With the increased studies on the effect of …
many cellular behaviors and functions. With the increased studies on the effect of …
[HTML][HTML] Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation
Mammalian cells rapidly respond to environmental changes by altering transmembrane
water and ion fluxes, changing cell volume. Contractile forces generated by actomyosin …
water and ion fluxes, changing cell volume. Contractile forces generated by actomyosin …
[HTML][HTML] Control of hydrostatic pressure and osmotic stress in 3D cell culture for mechanobiological studies
AP Kourouklis, A Wahlsten, A Stracuzzi, A Martyts… - Biomaterials …, 2023 - Elsevier
Hydrostatic pressure (HP) and osmotic stress (OS) play an important role in various
biological processes, such as cell proliferation and differentiation. In contrast to canonical …
biological processes, such as cell proliferation and differentiation. In contrast to canonical …
Osmotic regulation is required for cancer cell survival under solid stress
DJ McGrail, KM McAndrews, CP Brandenburg… - Biophysical journal, 2015 - cell.com
For a solid tumor to grow, it must be able to support the compressive stress that is generated
as it presses against the surrounding tissue. Although the literature suggests a role for the …
as it presses against the surrounding tissue. Although the literature suggests a role for the …
Regulation of cell behavior by hydrostatic pressure
S Liu, R Tao, M Wang, J Tian… - Applied …, 2019 - asmedigitalcollection.asme.org
Hydrostatic pressure (HP) regulates diverse cell behaviors including differentiation,
migration, apoptosis, and proliferation. Abnormal HP is associated with pathologies …
migration, apoptosis, and proliferation. Abnormal HP is associated with pathologies …