Cancer is a complex, multiscale process in which genetic mutations occurring at a
subcellular level manifest themselves as functional changes at the cellular and tissue scale …

The concept of biological adaptation was closely connected to some mathematical,
engineering and physical ideas from the very beginning. Cannon in his “The wisdom of the …

To establish and maintain organ structure and function, tissues need to balance stem cell
proliferation and differentiation rates and coordinate cell fate with position. By quantifying …

Despite major scientific, medical and technological advances over the last few decades, a
cure for cancer remains elusive. The disease initiation is complex, and including initiation …

The coordinated behaviour of populations of cells plays a central role in tissue growth and
renewal. Cells react to their microenvironment by modulating processes such as movement …

Even after a tumor is established, it can early on enter a state of dormancy marked by
balanced cell proliferation and cell death. Disturbances to this equilibrium may affect cancer …

We introduce a novel dynamic model of stem cell and tissue organisation in murine
intestinal crypts. Integrating the molecular, cellular and tissue level of description, this model …

Based on “bottom-up” strategy, cell-laden 3D bioprinting is an important process of
fabricating sophisticated biomimetic structures. Stem cell spheroids possess better …

Asthma is an obstructive airway disease, with a heterogeneous and multifactorial
pathogenesis. Although generally considered to be a disease principally driven by chronic …

In most instances, tumors have to push their surroundings in order to grow. Thus, during
their development, tumors must be able to both exert and sustain mechanical stresses …