There is emerging awareness that subchondral bone remodeling plays an important role in
the development of osteoarthritis (OA). This review presents recent investigations on the …

Osteoarthritis (OA) is the most common form of arthritic disease, and a major cause of
disability and impaired quality of life in the elderly. OA is a complex disease of the entire …

Background Osteoarthritis (OA), which is due to the progressive loss and degeneration of
articular cartilage, is the leading cause of disability worldwide. Therefore, it is of great …

Abstract Purpose of Review Osteoarthritis, the most common joint disease, is associated
with substantial medical costs, lost productivity, and reduced quality of life. However …

The role of osteoclasts in osteochondral degeneration in osteoarthritis (OA) has rarely been
investigated in spontaneous disease or animal models of OA. Objective The objectives of …

Osteomyelitis, an infectious disease predominantly tied to poor sanitary conditions in
underdeveloped regions of the world, is in need of inexpensive, easily in situ synthesizable …

Objective Monocytes contribute to synovitis and disease pathogenesis in osteoarthritis (OA).
Low-grade inflammation occurs in OA and correlates with disease severity and progression …

Although bone is one of the hardest tissues in the body, necessary for its structural and
protective roles, this organ is not static. Bone matrix must be renewed over time in order to …

Background Osteoclasts have been strongly implicated in osteoarthritic cartilage
degradation, at least indirectly via bone resorption, and have been shown to degrade …

Local priming of osteoclast precursors (OCp) has long been considered the main and
obvious pathway that takes place in the human body, where local bone lining cells and …