In the high-stakes arena of drug discovery, the journey from bench to bedside is hindered by
a daunting 92% failure rate, primarily due to unpredicted toxicities and inadequate …

Immunosuppressive medications are widely used to treat patients with neoplasms,
autoimmune conditions and solid organ transplants. Key drug classes, namely calcineurin …

Calcineurin inhibitors (CNI), including cyclosporine A (CsA) and tacrolimus (TAC), are
cornerstones of immunosuppressive therapy in solid organ transplant recipients. While …

Cardiovascular diseases persist as a global health challenge that requires methodological
innovation for effective drug development. Conventional pipelines relying on animal models …

Cardiac reactive fibrosis is a fibroblast-derived maladaptive process to tissue injury that
exacerbates an uncontrolled deposition of large amounts of extracellular matrix (ECM) …

Evidence linking the endothelium to cardiac injury in long coronavirus disease (COVID) is
well documented, but the underlying mechanisms remain unknown. Here we show that …

In recent years, significant biotechnological advancements have been made in engineering
human cardiac tissues and organ-like models. This field of research is crucial for both basic …

Abstract Purpose of Review This review explores the cardiovascular toxicity associated with
cancer therapies, emphasizing the significance of the growing field of cardio-oncology. It …

Artificial intelligence (AI)–enabled interpretation of electrocardiogram (ECG) images (AI-
ECGs) can identify patterns predictive of future adverse cardiac events. We hypothesized …

Since its inception, induced pluripotent stem cell (iPSC) technology has been hailed as a
powerful tool for comprehending disease etiology and advancing drug screening across …