DNA methylation is a stable epigenetic modification that contributes to the spatiotemporal
regulation of gene expression. The manner in which DNA methylation contributes to …

Tumour-specific antigens have been an area of interest in cancer therapy since their
discovery in the middle of the 20th century. In the era of immune-based cancer therapeutics …

Triple-negative breast cancer (TNBC) is a high-risk malignancy due to its high capacity for
invasion and lack of targeted therapy. Immunotherapy continues to demonstrate efficacy in a …

Cancer/testis antigens (CTAs) are named based on their expression pattern that is restricted
in a number of normal and abnormal tissues. Tumor cells frequently express antigens whose …

Tumor cells frequently exhibit widespread epigenetic aberrations that significantly alter the
repertoire of expressed proteins. In particular, it has been known for nearly 25 years that …

In 2015, lung cancer accounted for an estimated 221,200 new cancer diagnoses and
158,040 deaths in the United States, with the majority being attributable to cigarette …

Although immunotherapy continues to demonstrate efficacy in a variety of refractory cancers,
currently, no any immunotherapeutic strategy is clinically used for gastric cancer (GC) except …

The multifunctional zinc‐finger protein CCCTC‐binding factor (CTCF) is a very strong
candidate for the role of coordinating the expression level of coding sequences with their …

Background. Although immunotherapy has recently achieved clinical successes in a variety
of cancers, thus far there is no immunotherapeutic strategy for breast cancer (BC). Thus, it is …

Cancer germline (CG; also known as cancer-testis) antigen genes are normally expressed
in germ cells and trophoblast tissues and are aberrantly expressed in a variety of human …