Human development requires intricate cell specification and communication pathways that
allow an embryo to generate and appropriately connect more than 200 different cell types …

Inhibitor of DNA binding (ID) proteins are transcriptional regulators that control the timing of
cell fate determination and differentiation in stem and progenitor cells during normal …

The role of enhancers, a key class of non-coding regulatory DNA elements, in cancer
development has increasingly been appreciated. Here, we present the detection and …

Monoubiquitination of histone H2B on lysine 120 (H2Bub1) is an epigenetic mark generally
associated with transcriptional activation, yet the global functions of H2Bub1 remain poorly …

Members of the HECT family of E3 ubiquitin-protein ligases are characterized by a C-
terminal HECT domain that catalyzes the covalent attachment of ubiquitin to substrate …

Cancer chemoresistance and metastasis are tightly associated features. However, whether
they share common molecular mechanisms and thus can be targeted with one common …

Neddylation, the covalent attachment of ubiquitin-like protein Nedd8, of the Cullin-RING E3
ligase family regulates their ubiquitylation activity. However, regulation of HECT ligases by …

E3 ligases are a class of enzymes that can transfer ubiquitin to substrates for their
degradation, which are of importance in cellular homeostasis. Since many oncogenic or …

Smad ubiquitination regulatory factor 1 (Smurf1) and Smurf2 are HECT-type E3 ubiquitin
ligases, and both Smurfs were initially identified to regulate Smad protein stability in the TGF …

The NAD-dependent deacetylase sirtuin 1 (SIRT1), a member of the mammalian sirtuin
family, plays a pivotal role in deacetylating histone and nonhistone proteins. Recently, it has …