miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis

CE Condrat, DC Thompson, MG Barbu, OL Bugnar… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) represent a class of small, non-coding RNAs with the main roles of
regulating mRNA through its degradation and adjusting protein levels. In recent years …

RNA in extracellular vesicles

KM Kim, K Abdelmohsen, M Mustapic… - Wiley …, 2017 - Wiley Online Library
Cells release a range of membrane‐enclosed extracellular vesicles (EVs) into the
environment. Among them, exosomes and microvesicles (collectively measuring 40–1000 …

Spatial mapping of the total transcriptome by in situ polyadenylation

DW McKellar, M Mantri, MM Hinchman… - Nature …, 2023 - nature.com
Spatial transcriptomics reveals the spatial context of gene expression, but current methods
are limited to assaying polyadenylated (A-tailed) RNA transcripts. Here we demonstrate that …

MicroRNA as biomarkers and diagnostics

J Wang, J Chen, S Sen - Journal of cellular physiology, 2016 - Wiley Online Library
MicroRNAs (miRNAs) are a group of small non‐coding RNAs that are involved in regulating
a range of developmental and physiological processes; their dysregulation has been …

The role of microRNAs in neurodegenerative diseases: a review

S Li, Z Lei, T Sun - Cell Biology and Toxicology, 2023 - Springer
MicroRNAs (miRNAs) are non-coding RNAs which are essential post-transcriptional gene
regulators in various neuronal degenerative diseases and playact a key role in these …

[HTML][HTML] Muscle-specific microRNAs in skeletal muscle development

M Horak, J Novak, J Bienertova-Vasku - Developmental biology, 2016 - Elsevier
Proper muscle function constitutes a precondition for good heath and an active lifestyle
during an individual's lifespan and any deviations from normal skeletal muscle development …

Micro RNA s in metabolism

S Vienberg, J Geiger, S Madsen… - Acta …, 2017 - Wiley Online Library
Micro RNA s (mi RNA s) have within the past decade emerged as key regulators of
metabolic homoeostasis. Major tissues in intermediary metabolism important during …

Updated review of advances in microRNAs and complex diseases: experimental results, databases, webservers and data fusion

L Huang, L Zhang, X Chen - Briefings in bioinformatics, 2022 - academic.oup.com
MicroRNAs (miRNAs) are gene regulators involved in the pathogenesis of complex
diseases such as cancers, and thus serve as potential diagnostic markers and therapeutic …

Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations

I Prada, M Gabrielli, E Turola, A Iorio, G D'Arrigo… - Acta …, 2018 - Springer
Recent evidence indicates synaptic dysfunction as an early mechanism affected in
neuroinflammatory diseases, such as multiple sclerosis, which are characterized by chronic …

Biogenesis and regulation of the let-7 miRNAs and their functional implications

H Lee, S Han, CS Kwon, D Lee - Protein & cell, 2016 - academic.oup.com
The let-7 miRNA was one of the first miRNAs discovered in the nematode, Caenorhabditis
elegans, and its biological functions show a high level of evolutionary conservation from the …