The discovery of human pluripotent stem cells (hPSCs), including both human embryonic
stem cells and human-induced pluripotent stem cells, has opened up novel paths for a wide …

Myocardial infarction (MI) is still the leading cause of mortality worldwide. The success of cell-
based therapies and tissue engineering strategies for treatment of injured myocardium have …

The connexin family of channel-forming proteins is present in every tissue type in the human
anatomy. Connexins are best known for forming clustered intercellular channels, structurally …

Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Gap junctions (Gj) form conduits between adjacent cells that are composed of connexin (Cx)
protein subunits and allow direct intercellular communication. To date, the connexin gene …

Current methods to differentiate cardiomyocytes from human pluripotent stem cells (PSCs)
inadequately recapitulate complete development and result in PSC-derived cardiomyocytes …

Sáez, Juan C., Viviana M. Berthoud, María C. Brañes, Agustín D. Martínez, and Eric C.
Beyer. Plasma Membrane Channels Formed by Connexins: Their Regulation and Functions …

Heterozygous Tbx5 del/+ mice were generated to study the mechanisms by which TBX5
haploinsufficiency causes cardiac and forelimb abnormalities seen in Holt-Oram syndrome …

The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …

Abstract Plakophilin-2 (PKP2) is a component of the desmosome and known for its role in
cell–cell adhesion. Mutations in human PKP2 associate with a life-threatening …