Molecular chaperones play central roles in sustaining protein homeostasis and preventing
protein aggregation. Most studies of these systems have been performed in bulk, providing …

Talin as a critical focal adhesion mechanosensor exhibits force-dependent folding dynamics
and concurrent interactions. Being a cytoplasmic protein, talin also might interact with …

Single-molecule force spectroscopy provides access to the mechanics of biomolecules.
Recently, magnetic and laser optical tweezers were applied in the studies of chaperones …

Protein folding under force is an integral source of generating mechanical energy in various
cellular processes, ranging from protein translation to degradation. Although chaperones …

Polypeptide chains experience mechanical tension while translocating through cellular
tunnels, which are subsequently folded by molecular chaperones. However, interactions …

Gram‐positive bacteria experience considerable mechanical perturbation when adhering to
host surfaces during colonization and infection. They have evolved various adhesion …

Protein quality control in the endoplasmic reticulum (ER) maintains cellular proteostasis by
regulating protein folding, assembly, and degradation. While protein translocation from the …

Polypeptide chains experiences mechanical tension while translocating through cellular
tunnel. In this scenario, interaction of tunnel-associated chaperones with the emerging …

Studies of free energy, kinetics or elasticity are common to most disciplines of science.
Detailed quantification of these properties demands number of specialized technologies …

Protein folding under force is an integral source of generating mechanical power to carry out
diverse cellular functions. Though chaperones interact with proteins throughout the different …