Schizophrenia is a prevalent complex trait disorder manifested by severe neurocognitive
dysfunctions and lifelong disability. During the past few years several studies have provided …

Dopamine D2 receptor antagonism is a unifying property of all antipsychotic drugs in clinical
use. Remarkably, the effector molecules through which these medications exert their actions …

Dopamine D2 receptors are involved with wakefulness, but their role in the decreased
alertness associated with sleep deprivation is unclear. We had shown that sleep deprivation …

Recent evidence suggests that SARS-CoV-2 hinders immune responses via dopamine (DA)-
related mechanisms. Nonetheless, studies addressing the specific role of DA in the frame of …

Rationale This review attempts to summarize the current status in relation to the use of
positron emission tomography (PET) imaging in the assessment of synaptic concentrations …

We investigated the role of G protein-coupled receptor kinase (GRK)-mediated
phosphorylation in agonist-induced desensitization, arrestin association, endocytosis, and …

Signaling bias is the propensity for some agonists to preferentially stimulate G protein–
coupled receptor (GPCR) signaling through one intracellular pathway versus another. We …

Dopamine released by amphetamine decreases the in vivo binding of PET radioligands to
the dopamine D2 receptor. Although concentrations of extracellular dopamine largely return …

Recent genetic, molecular and post-mortem studies suggest impaired dopamine (DA)-D2
receptor (D2R) trafficking in patients with schizophrenia (SZ). Imaging and preclinical …

While all reversible receptor-targeting radioligands for positron emission tomography (PET)
can be displaced by competition with an antagonist at the receptor, many radiotracers show …