Has ferrocene really delivered its role in accentuating the bioactivity of organic scaffolds?

B Sharma, V Kumar - Journal of medicinal chemistry, 2021 - ACS Publications
Ferrocene is an important structural core in bioorganometallic chemistry because of its
inherent stability, excellent redox properties, and low toxicity. Ferroquine and ferrocifen are …

Quinolines, a perpetual, multipurpose scaffold in medicinal chemistry

P Yadav, K Shah - Bioorganic Chemistry, 2021 - Elsevier
Quinoline is a versatile pharmacophore, a privileged scaffold and an outstanding fused
heterocyclic compound with a wide range of pharmacological prospective such as …

Ferrocene-containing hybrids as potential anticancer agents: Current developments, mechanisms of action and structure-activity relationships

R Wang, H Chen, W Yan, M Zheng, T Zhang… - European Journal of …, 2020 - Elsevier
Cancer is one of the most fatal threatens to human health throughout the world. The major
challenges in the control and eradication of cancers are the continuous emergency of drug …

Insights of 8-hydroxyquinolines: A novel target in medicinal chemistry

R Gupta, V Luxami, K Paul - Bioorganic chemistry, 2021 - Elsevier
Hydroxyquinoline (8-HQ) is a significant heterocyclic scaffold in organic and analytical
chemistry because of the properties of chromophore and is used to detect various metal ions …

Facing diseases caused by trypanosomatid parasites: rational design of Pd and Pt complexes with bioactive ligands

D Gambino, L Otero - Frontiers in Chemistry, 2022 - frontiersin.org
Human African Trypanosomiasis (HAT), Chagas disease or American Trypanosomiasis
(CD), and leishmaniases are protozoan infections produced by trypanosomatid parasites …

Heteroleptic Oxidovanadium(V) Complexes with Activity against Infective and Non-Infective Stages of Trypanosoma cruzi

G Scalese, I Machado, G Salinas, L Pérez-Díaz… - Molecules, 2021 - mdpi.com
Five heteroleptic compounds,[VVO (IN-2H)(LH)], where L are 8-hydroxyquinoline derivatives
and IN is a Schiff base ligand, were synthesized and characterized in both the solid and …

When ferrocene and diiron organometallics meet: triiron vinyliminium complexes exhibit strong cytotoxicity and cancer cell selectivity

S Schoch, S Braccini, L Biancalana, A Pratesi… - Inorganic Chemistry …, 2022 - pubs.rsc.org
Cationic triiron complexes resulting from the conjugation of the ferrocenyl skeleton (Fc) with
a diiron bis-cyclopentadienyl core through a variable vinyliminium linker,[Fe2Cp2 (CO)(μ …

Quantum chemical and biological insights into redox activity of metallacarborane complexes in cancer cells

K Bednarska-Szczepaniak, K Hałagan… - Journal of Chemical …, 2024 - ACS Publications
A relationship between the electronic properties of metal ions in metallacarboranes and their
ability to modulate mitochondrial oxidase activity and membrane hyperpolarization in cancer …

New multifunctional Ru (II) organometallic compounds show activity against Trypanosoma brucei and Leishmania infantum

F Rivas, C Del Mármol, G Scalese, L Pérez-Díaz… - Journal of Inorganic …, 2022 - Elsevier
Human African trypanosomiasis (sleeping sickness) and leishmaniasis are prevalent
zoonotic diseases caused by genomically related trypanosomatid protozoan parasites …

Solution chemistry and anti-proliferative activity against glioblastoma cells of a vanadium (V) complex with two bioactive ligands

A Levina, G Scalese, D Gambino, DC Crans… - Frontiers in Chemical …, 2024 - frontiersin.org
Introduction: Glioblastoma is a brain cancer difficult to treat but recently mixed-ligand
vanadium (V) Schiff base/catecholato complexes have exhibited high in vitro anti …