Biomolecular condensates are membraneless intracellular assemblies that often form via
liquid− liquid phase separation and have the ability to concentrate biopolymers. Research …

Cells are exquisitely compartmentalized to achieve precise spatiotemporal regulation of
myriad processes and pathways. Phase separation offers one way to achieve territorial …

INTRODUCTION The nucleus harbors and protects the genetic information in eukaryotes. It
is surrounded by the nuclear envelope, which separates the nucleoplasm from the cytosol …

Abstract α-Synuclein (α-Syn) aggregation and amyloid formation is directly linked with
Parkinson's disease pathogenesis. However, the early events involved in this process …

Biomolecular condensation partitions cellular contents and has important roles in stress
responses, maintaining homeostasis, development and disease. Many nuclear and …

Optimum protein function and biochemical activity critically depends on water availability
because solvent thermodynamics drive protein folding and macromolecular interactions …

Many organisms evolved strategies to survive desiccation. Plant seeds protect dehydrated
embryos from various stressors and can lay dormant for millennia. Hydration is the key …

BACKGROUND Living cells contain distinct subcompartments to facilitate spatiotemporal
regulation of biological reactions. In addition to canonical membrane-bound organelles such …

INTRODUCTION The formation of dynamic, membraneless compartments using intracellular
phase transitions such as phase separation and gelation provides an efficient way for cells …

In eukaryotic cells, diverse stresses trigger coalescence of RNA-binding proteins into stress
granules. In vitro, stress-granule-associated proteins can demix to form liquids, hydrogels …