Oxidative stress and free radicals in COPD–implications and relevance for treatment

W Domej, K Oettl, W Renner - International journal of chronic …, 2014 - Taylor & Francis
Oxidative stress occurs when free radicals and other reactive species overwhelm the
availability of antioxidants. Reactive oxygen species (ROS), reactive nitrogen species, and …

Peroxynitrite: biochemistry, pathophysiology and development of therapeutics

C Szabó, H Ischiropoulos, R Radi - Nature reviews Drug discovery, 2007 - nature.com
Peroxynitrite—the product of the diffusion-controlled reaction of nitric oxide with superoxide
radical—is a short-lived oxidant species that is a potent inducer of cell death. Conditions in …

Redox-active radical scavenging nanomaterials

A Karakoti, S Singh, JM Dowding, S Seal… - Chemical Society …, 2010 - pubs.rsc.org
Reactive oxygen and nitrogen species play a critical role in many degenerative diseases
and in aging. Nanomaterials, especially modified fullerenes and cerium oxide nanoparticles …

Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential

I Batinić-Haberle, JS Rebouças… - Antioxidants & redox …, 2010 - liebertpub.com
Oxidative stress has become widely viewed as an underlying condition in a number of
diseases, such as ischemia–reperfusion disorders, central nervous system disorders …

Oxidants, antioxidants and the ischemic brain

DS Warner, H Sheng… - Journal of experimental …, 2004 - journals.biologists.com
Despite numerous defenses, the brain is vulnerable to oxidative stress resulting from
ischemia/reperfusion. Excitotoxic stimulation of superoxide and nitric oxide production leads …

The antioxidant effect of the metal and metal-oxide nanoparticles

X Ge, Z Cao, L Chu - Antioxidants, 2022 - mdpi.com
Inorganic nanoparticles, such as CeO3, TiO2 and Fe3O4 could be served as a platform for
their excellent performance in antioxidant effect. They may offer the feasibility to be further …

Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy

P Kirkham, I Rahman - Pharmacology & therapeutics, 2006 - Elsevier
Asthma and chronic obstructive pulmonary disease (COPD) are inflammatory lung diseases
that are characterized by systemic and chronic localized inflammation and oxidative stress …

Cerium oxide nanoparticles scavenge nitric oxide radical (˙ NO)

JM Dowding, T Dosani, A Kumar, S Seal… - Chemical …, 2012 - pubs.rsc.org
In this study we have obtained evidence that cerium oxide nanoparticles (CeO2 NPs) are
able to scavenge nitric oxide radical. Surprisingly, this activity is present in CeO2 NPs with a …

Transition metal salen complexes in bioinorganic and medicinal chemistry

A Erxleben - Inorganica Chimica Acta, 2018 - Elsevier
Salen is a common abbreviation for tetradentate N 2 O 2 bis-Schiff base bis-phenolate
ligands. Due to the ease of their synthesis, rich coordination chemistry and photophysical …

SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways

I Batinic-Haberle, A Tovmasyan… - Antioxidants & redox …, 2014 - liebertpub.com
Significance: Superoxide dismutase (SOD) enzymes are indispensable and ubiquitous
antioxidant defenses maintaining the steady-state levels of O2·−; no wonder, thus, that their …