Recent advances in machine perfusion have revolutionised the field of transplantation by
prolonging preservation, permitting evaluation of viability prior to implant and rescue of …

The normal liver has an extraordinary capacity of regeneration. However, this capacity is
significantly impaired in steatotic livers. Emerging evidence indicates that metabolic …

Bile duct regeneration is hypothesized to prevent biliary strictures, a leading cause of
morbidity after liver transplantation. Assessing the capacity for biliary regeneration may …

To fully harness mesenchymal-stromal-cells (MSCs)'benefits during Normothermic Machine
Perfusion (NMP), we developed an advanced NMP platform coupled with a MSC-bioreactor …

Developing clinically predictive model systems for evaluating gene transfer and gene editing
technologies has become increasingly important in the era of personalized medicine. Liver …

The shortage of donor organs remains an unresolved issue in liver transplantation
worldwide. Consequently, strategies for expanding the donor pool are currently being …

Background Ex situ machine perfusion facilitates the assessment of livers prior to
transplantation. However, currently available markers of liver function poorly predict long …

Background Normothermic machine perfusion (NMP) allows for the assessment and
resuscitation of ex‐vivo human livers prior to transplantation. Commercially available NMP …

Background Normothermic machine perfusion of donor livers has become standard practice
in the field of transplantation, allowing the assessment of organs and safe extension of …

Adeno-associated viruses (AAVs) are non-pathogenic, replication-deficient viruses that have
gained widespread attention for their application as gene therapy vectors. While these …