Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets
R Qin, FM You, Q Zhao, X Xie, C Peng, G Zhan… - Journal of hematology & …, 2022 - Springer
Regulated cell death (RCD) is a critical and active process that is controlled by specific
signal transduction pathways and can be regulated by genetic signals or drug interventions …
signal transduction pathways and can be regulated by genetic signals or drug interventions …
[HTML][HTML] Exploring the anticancer activities of novel bioactive compounds derived from endophytic fungi: mechanisms of action, current challenges and future …
R Kousar, M Naeem, MI Jamaludin… - American Journal of …, 2022 - ncbi.nlm.nih.gov
Cancer is the second leading cause of death all around the world. The natural compounds
derived from the endophytic flora of fungi are possible solutions to cancer treatment because …
derived from the endophytic flora of fungi are possible solutions to cancer treatment because …
Discovery of new quinolines as potent colchicine binding site inhibitors: Design, synthesis, docking studies, and anti-proliferative evaluation
M Hagras, MA El Deeb, HSA Elzahabi… - Journal of Enzyme …, 2021 - Taylor & Francis
Discovering of new anticancer agents with potential activity against tubulin polymerisation is
still a promising approach. Colchicine binding site inhibitors are the most relevant anti …
still a promising approach. Colchicine binding site inhibitors are the most relevant anti …
Design and synthesis of novel benzoazoninone derivatives as potential CBSIs and apoptotic inducers: in vitro, in vivo, molecular docking, molecular dynamics, and …
Apparently, tubulin inhibitors binding to the colchicine-binding site (CBS) currently have
outstanding attention for cancer treatment. So, a series of benzo [b] azonin-2-one derivatives …
outstanding attention for cancer treatment. So, a series of benzo [b] azonin-2-one derivatives …
Intrinsic and extrinsic factors affecting microtubule dynamics in normal and cancer cells
F Borys, E Joachimiak, H Krawczyk, H Fabczak - Molecules, 2020 - mdpi.com
Microtubules (MTs), highly dynamic structures composed of α-and β-tubulin heterodimers,
are involved in cell movement and intracellular traffic and are essential for cell division …
are involved in cell movement and intracellular traffic and are essential for cell division …
Design, eco-friendly synthesis, molecular modeling and anticancer evaluation of thiazol-5 (4 H)-ones as potential tubulin polymerization inhibitors targeting the …
In recent years, suppressing tubulin polymerization has been developed as a therapeutic
approach for cancer treatment. Thus, new derivatives based on thiazol-5 (4H)-ones have …
approach for cancer treatment. Thus, new derivatives based on thiazol-5 (4H)-ones have …
Combination of microtubule targeting agents with other antineoplastics for cancer treatment
T Liang, L Lu, X Song, J Qi, J Wang - … et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
Microtubule targeting agents (MTAs) have attracted extensive attention for cancer treatment.
However, their clinical efficacies are limited by intolerable toxicities, inadequate efficacy and …
However, their clinical efficacies are limited by intolerable toxicities, inadequate efficacy and …
[HTML][HTML] Biotechnological approaches to the production of plant-derived promising anticancer agents: An update and overview
The plant kingdom is a rich source of bioactive compounds, many of which have been used
since pre-history for their therapeutic properties to treat a range of illnesses. These …
since pre-history for their therapeutic properties to treat a range of illnesses. These …
Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect
TS Ibrahim, MM Hawwas, AM Malebari… - Journal of Enzyme …, 2021 - Taylor & Francis
A new series of quinoline derivatives of combretastatin A-4 have been designed,
synthesised and demonstrated as tubulin polymerisation inhibitors. These novel compounds …
synthesised and demonstrated as tubulin polymerisation inhibitors. These novel compounds …
An acetylation mimicking mutation, K274Q, in tau imparts neurotoxicity by enhancing tau aggregation and inhibiting tubulin polymerization
In Alzheimer's disease, tau is predominantly acetylated at K174, K274, K280, and K281
residues. The acetylation of K274-tau is linked with memory loss and dementia. In this study …
residues. The acetylation of K274-tau is linked with memory loss and dementia. In this study …