Background: Leukemia is a malignant disease that threatens human health and life. Nano-
delivery systems improve drug solubility, bioavailability, and blood circulation time, and …

Drug repositioning is defined as a process to identify a new application for drugs. This
approach is critical as it takes advantage of well-known pharmacokinetics …

Despite recent advances in acute myeloid leukemia (AML) molecular characterization and
targeted therapies, a majority of AML cases still lack therapeutically actionable targets. In …

Pyrvinium, a lipophilic cation belonging to the cyanine dye family, has been used in the
clinic as a safe and effective anthelminthic for over 70 years. Its structure, similar to some …

B-cell acute lymphoblastic leukemia (ALL) is characterized by accumulation of immature
hematopoietic cells in the bone marrow, a well-established sanctuary site for leukemic cell …

Drastically elevated glycolytic activity is a prominent metabolic feature of cancer cells. Until
recently it was thought that tumor cells shift their entire energy production from oxidative …

B-cell acute lymphoblastic leukemia (ALL) affects both pediatric and adult patients.
Chemotherapy resistant tumor cells that contribute to minimal residual disease (MRD) …

Simple Summary Chemoresistance leads to poor prognostic outcomes in leukemic patients.
Investigating the effects of pitavastatin in chemo-resistant ALL cells provides support for …

During the development of leukemia, the overgrowth of leukemia cells in the bone marrow
transforms the normal hematopoietic microenvironment into the leukemia microenvironment …

Pediatric MLL-rearranged acute myeloid leukemia (AML) has a generally unfavorable
outcome, primarily due to relapse and drug resistance. To overcome these difficulties, new …