Pompe disease (glycogen storage disease type II) is caused by mutations in acid α-
glucosidase (GAA) resulting in lysosomal pathology and impairment of the muscular and …

Tendon is a vital connective tissue in human skeletal muscle system, and tendon injury is
very common and intractable in clinic. Tendon development and repair are two closely …

Tendons are specialized tissues composed primarily of load-responsive fibroblasts
(tenocytes) embedded in a collagen-rich extracellular matrix. Habitual mechanical loading …

Tendons and tendon interfaces have a very limited regenerative capacity, rendering their
injuries clinically challenging to resolve. Tendons sense muscle-mediated load; however …

Background Although mesenchymal stem cells (MSCs) have been effective in tendinopathy,
the mechanisms by which MSCs promote tendon healing have not been fully elucidated. In …

Poly L-lactic acid (PLLA) fillers stimulate collagen synthesis by activating various immune
cells and fibroblasts. Piezo1, an ion channel, responds to mechanical stimuli, including …

Understanding the myofibroblast microenvironment is critical to developing therapies for
fibrotic diseases. Here the development of a novel human tendon‐on‐a‐chip (hToC) is …

Rotator cuff repair failure remains common due to poor tendon healing, particularly at the
enthesis. We previously showed that pulsed electromagnetic field (PEMF) therapy improved …

The tendon is highly prone to injury, overuse, or age‐related degeneration in both humans
and horses. Natural healing of injured tendon is poor, and cell‐based therapeutic treatment …

Transforming growth factor‐beta (TGF‐β1) induces plasminogen activator inhibitor 1 (PAI‐1)
to effect fibrotic pathologies in several organs including tendon. Recent data implicated PAI …