The peroxisome proliferator-activated receptor: A family of nuclear receptors role in various diseases

S Tyagi, P Gupta, AS Saini, C Kaushal… - Journal of advanced …, 2011 - journals.lww.com
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription
factors of nuclear hormone receptor superfamily comprising of the following three subtypes …

Antineoplastic effects of peroxisome proliferatoractivated receptor γ agonists

C Grommes, GE Landreth, MT Heneka - The lancet oncology, 2004 - thelancet.com
Peroxisome proliferator-activated receptors (PPAR) are members of a superfamily of nuclear
hormone receptors. Activation of PPAR isoforms elicits both antineoplastic and anti …

Localization of PPAR isotypes in the adult mouse and human brain

A Warden, J Truitt, M Merriman, O Ponomareva… - Scientific reports, 2016 - nature.com
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that act
as ligand-activated transcription factors. PPAR agonists have well-documented anti …

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that β-cell death is caspase mediated, partially …

R Lupi, F Dotta, L Marselli, S Del Guerra, M Masini… - Diabetes, 2002 - Am Diabetes Assoc
In an effort to better understand the phenomenon of lipotoxicity in human β-cells, we
evaluated the effects of 48-h preculture with 1.0 or 2.0 mmol/l free fatty acid (FFA)(2: 1 oleate …

PPARs in the brain

MT Heneka, GE Landreth - Biochimica et biophysica acta (BBA)-molecular …, 2007 - Elsevier
The biology of peroxisome proliferator activated receptors (PPARs) in physiological and
pathophysiological processes has been primarily studied in peripherial organs and tissues …

Peroxisome proliferator‐activated receptor‐γ agonists prevent experimental autoimmune encephalomyelitis

DL Feinstein, E Galea, V Gavrilyuk… - Annals of Neurology …, 2002 - Wiley Online Library
The development of clinical symptoms in multiple sclerosis and its animal model
experimental autoimmune encephalomyelitis (EAE) involves T‐cell activation and migration …

PPAR-γ agonists as regulators of microglial activation and brain inflammation

A Bernardo, L Minghetti - Current pharmaceutical design, 2006 - ingentaconnect.com
The peroxisome proliferator-activated receptor-g (PPAR-γ) belongs to a large group of
nuclear receptors controlling reproduction, metabolism, development and immune …

Peroxisome proliferator‐activated receptor γ activators affect the maturation of human monocyte‐derived dendritic cells

P Gosset, AS Charbonnier, P Delerive… - European journal of …, 2001 - Wiley Online Library
Peroxisome proliferator‐activated receptor γ (PPARγ), a member of the nuclear receptor
superfamily, has recently been described as a modulator of macrophage functions and as …

MiR-27b targets PPARγ to inhibit growth, tumor progression and the inflammatory response in neuroblastoma cells

JJ Lee, A Drakaki, D Iliopoulos, K Struhl - Oncogene, 2012 - nature.com
The peroxisome proliferators-activated receptor (PPAR) γ pathway is involved in cancer, but
it appears to have both tumor suppressor and oncogenic functions. In neuroblastoma cells …

Anti-inflammatory actions of peroxisome proliferator-activated receptor gamma agonists in Alzheimer's disease

GE Landreth, MT Heneka - Neurobiology of aging, 2001 - Elsevier
The role of inflammatory processes in the brains of Alzheimer's Disease (AD) patients has
recently attracted considerable interest. Indeed, the only demonstrated effective therapy for …