Proteases are signaling molecules that specifically control cellular functions by cleaving
protease-activated receptors (PARs). The four known PARs are members of the large family …

A great deal of experimental evidence suggests that ligands can stabilize different receptor
active states that go on to interact with cellular signaling proteins to form a range of different …

Abstract Background Dr. Athina Markou sought treatments for a common neural substrate
shared by depression and drug dependence. Antagonists of corticotropin-releasing factor …

Sensory nerves are equipped with receptors and ion channels that allow them to detect and
respond to diverse chemical, mechanical, and thermal stimuli. These sensory proteins …

Oral squamous cell carcinoma (OSCC) is one of the most painful cancers, which interferes
with orofacial function including talking and eating. We report that legumain (Lgmn) cleaves …

Protease-activated receptor-2 (PAR2) has been extensively studied since its discovery in the
mid-1990. Despite the advances in understanding PAR2 pharmacology, it has taken almost …

Abstract Protease-activated receptor-2 (PAR2) has been implicated in multiple
pathophysiologies but drug discovery is challenging due to low small molecule tractability …

Abstract Protease-activated receptor-2 (PAR2) is involved in inflammatory responses and
pain, therefore representing a promising therapeutic target for the treatment of immune …

The occurrence of allergic diseases induced by aeroallergens has increased in the past
decades. Among inhalant allergens, mites remain the important causal agent of allergic …

Inflammatory diseases have become increasingly prevalent throughout the world.
Coronavirus disease 2019 (COVID‐19), which has recently become pandemic, also exhibits …