Bone regeneration is a complex, well-orchestrated physiological process of bone formation,
which can be seen during normal fracture healing, and is involved in continuous …

Bone vasculature plays a vital role in bone development, remodeling and homeostasis. New
blood vessel formation is crucial during both primary bone development as well as fracture …

Vascularization of large bone grafts is one of the main challenges of bone tissue
engineering (BTE), and has held back the clinical translation of engineered bone constructs …

The lack of a functional vascular supply has, to a large extent, hampered the whole range of
clinical applications of 'successful'laboratory‐based bone tissue engineering strategies. To …

Endothelial progenitor cells (EPCs) are currently being studied as candidate cell sources for
revascularization strategies. Significant advances have been made in understanding the …

BACKGROUND: The use of bone marrow concentrate (BMC) for treatment of
musculoskeletal disorders has become increasingly popular over the last several years, as …

Despite its natural healing potential, bone is unable to regenerate sufficient tissue within
critical‐sized defects, resulting in a non‐union of bone ends. As a consequence …

Context: Type 2 diabetes mellitus (T2D) is associated with an increased risk of fractures and
low bone formation. However, the mechanism for the low bone formation is not well …

The enhancement of bone regeneration with biological agents including osteogenic growth
factors and mesenchymal stem cells (MSCs) is becoming a clinical reality. Many exciting …

Background Repair of large-sized bone defects is a challengeable obstacle in orthopedics
and evoked the demand for the development of biomaterials that could induce bone repair …