Articular cartilage (AC) sheathes joint surfaces and minimizes friction in diarthrosis. The
resident cell population, chondrocytes, are surrounded by an extracellular matrix and a …

Current treatments for rheumatoid arthritis (RA) do not work well for a large proportion of
patients, or at all in some individuals, and cannot cure or prevent this disease. One major …

Damaged hyaline cartilage has no capacity for self-healing, making osteoarthritis
(OA)“difficult-to-treat”. Cartilage destruction is central to OA patho-etiology and is mediated …

Decline in biological resilience (ability to recover) is a key manifestation of aging that
contributes to increase in vulnerability to death with age eventually limiting longevity even in …

Objective In this review, we have highlighted advances in genetics, genomics and
epigenetics in the field of osteoarthritis (OA) over the past year. Methods A literature search …

Osteoarthritis (OA) is among the most frequent diseases of the musculoskeletal system.
Degradation of cartilage extracellular matrix (ECM) is a hallmark of OA. During the …

The ultimate hope of researchers and patients is a pathway to development of treatments for
osteoarthritis to modify the disease process in addition to the symptoms. However …

Alkaptonuria (AKU) is a rare disease characterized by high levels of homogentisic acid
(HGA); patients suffer from tissue ochronosis: dark brown pigmentation, especially of joint …

Collagen-rich tissues have poor reparative capacity that predisposes to common age-
related disorders such as osteoporosis and osteoarthritis. We used in vivo pulsed SILAC …

The osteochondral (OC) unit plays a pivotal role in joint lubrication and in the transmission of
constraints to bones during movement. The OC unit does not spontaneously heal; therefore …